; Pyrogens Comply with the requirements slated under Carbenicillin Sodium.

following requiremants. Description While or almost while powder, odourless, hygroscopic. Identification; pH. Specific optical rotation; Iodine absorbing substances; Water; Pyrogens Comply with the requirements slated under Carbenicillin Sodium. Assay Carry out the Assay described under Carbenicillin Sodium using the mixed contents of 10 containers. CARBEN0X0LONE SODIUMC34H48Na2Q7, Wt 614.70 Carbenoxolone Sodium is disodium 3B-(3-carboxyl-atopropionyloxy)-11-oxo-olean-l2-en-30-Oate. Category Ulcer-healing drug in gastric ulcer Dose 300 nig daily, in divided doses for 1 week, subsequently, uplo 150 mg daily, in divided doses Description White or pale cream powder, hygroscopic, irritant to nasal membranes.Solubility Freely soluble in water, soluble in elhanol (95%), practically insoluble in chloroform and in ether Storage Store in well-closed containers STANDARDSCarbenonolone Sodium contains nol less than 97.0 per cent and not more than 103.0 per cent of C34H48Na2Q7L calculated with reference to the anhydrous substance. Identification A Dissolve 0.1 g in 5 ml of water, just acidify with 2M hydrochloric acidH stir well and filler Wash the residue with water until the washings are no longer acidic and dry to constant weight at 105° The infra-red absorption spectrum, Appendix S. 4, of the residue is concordant with the reference spectrum of carbenoxolone or with the spectrum obtained from carbenoxctone sodium RS Treaied in The same manner. B. The light absorption in the range 230 10 3EO nm of a 0.0025% w/v solution in a mixture of equal volumes of methanol and 0.02M sodium carbonate exhibits a maximum only at about 266 nm,h absorbance at about 256 nm, about 0.5, Appendix 5.5.C: